Sheberla, D.; Sun, L.; Blood-Forsythe, M. A.; Er, S.; Wade, C. R.; Brozek, C. K.; Aspuru-Guzik, A.; Dincă, M. J. Am. Chem. Soc. 2014. APAP. DOI:10.1021/ja502765n Reaction of ...
Monthly Archives: May 2014
Koichi Tanaka
Koichi Tanaka (born 1959, Toyama, Japan) is a Japanese analytical chemist and engineer, who shared the Nobel Prize in Chemistry in 2002 for developing a novel method for mass spectrometric analyses ...
#8: Professor Tamio Hayashi: Selectively creating enantiomers using unique catalysts
This interview series has been around for a few months now, and has received many positive reviews. We appreciate your encouragement and we would like to continue this series. For this 8th interview, ...
Control of Surface Wettability Using Tripodal Light-Activated Molecular Motors
Chen, K.-Y.; Ivashenko, O.; Carroll, G. T.; Robertus, J.; Kistemaker, J. C. M.; London, G.; Browne, W. R.; Rudolf, P.; Feringa, B. L. J. Am. Chem. Soc. 2014. 136, 3219–3224. DOI: 10.1021/ja412110t ...
Serine-Selective Aerobic Cleavage of Peptides and a Protein Using a Water-Soluble Copper–Organoradical Conjugate
Seki, Y.; Tanabe, K.; Sasaki, D.; Sohma, Y.; Oisaki, K.; Kanai, M. Angew. Chem. Int. Ed. 2014, 53, Early View. DOI: 10.1002/anie.201402618 The site-specific cleavage of peptide bonds is an important ...
Febuxostat
Febuxostat is an inhibitor of xanthine oxidase, and was developed by Teijin pharma. This compound is known as a new drug that is effective against gout and hyperuricemia, and it has been 40 ...
Fusing N-Heterocyclic Carbenes with Carborane Anion
El-Hellanid, A.; Lavallo, V. Angew. Chem. Int. Ed. 53, 2014. 4489-4493. DOI: 10.1002/anie.201402445 Fusion of two families of unusual carbon-containing molecules that readily disregard the tendency ...
Kumada-Tamao-Corriu Cross Coupling
General Characteristics The palladium- or nickel-catalyzed cross coupling between aryl halides/triflates and Grignard reagents is known as the Kumada-Tamao-Corriu reaction. The Kumada-Tamao-Corriu ...
Malaprade Glycol Oxidative Cleavage
General Characteristics Periodic acid or sodium periodate is used to oxidatively cleave 1,2-diols, producing a pair of aldehydes or ketones. Sodium periodate also works as the reoxidant of osmium ...
Corey-Fuchs Alkyne Synthesis
General Characteristics The Corey-Fuchs reaction is the conversion of aldehydes into alkynes with one carbon homologation. The treatment of 1,1-dihaloalkenes with 2 equivalents of alkyllithium gives ...