Monthly Archives: July 2015

Oxidative Coupling of Enolates

Oxidative Coupling of Enolates

General Characteristics Enolate species undergo dimerization under appropriately chosen oxidative conditions. Homo-coupling usually predominates, but there are successful examples of controlled ...

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Kharasch-Sosnovsky Oxidation

Kharasch-Sosnovsky Oxidation

General Characteristics Allylic C-H oxidation can be effected using acylperoxide under copper-catalyzed conditions. The alkene starting materials are usually used in excess. The terminal olefins are ...

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Selenium Dioxide

Selenium Dioxide

General Characteristics Selenium dioxide oxidizes allylic C-H bonds, providing an option to synthesize allylic alcohols from alkenes. Even though SeO2 is a toxic reagent, it is used frequently since ...

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C-H Oxidation with NHPI Catalyst

C-H Oxidation with NHPI Catalyst

General Characteristics An organocatalyst N-hydroxyphthalimide (NHPI) forms the strongly oxidizing N-oxyl radical species (PINO) in the presence of appropriate oxidizing agents. This radical is ...

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Collman’s Reagent

Collman’s Reagent

General Characteristics Disodium tetracarbonylferrate is generally referred to as the Collman reagent. It reacts with alkyl halides to give corresponding aldehydes and ketones. General References ...

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