Monthly Archives: November 2015

Blum-Ittah Aziridine Synthesis

Blum-Ittah Aziridine Synthesis

General Characteristics Epoxides can be converted into aziridines by nucleophilic attack of azide ion, the Staudinger reaction, and aziridine ring formation with elimination of triphenylphosphine ...

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C-C Bond Activation

C-C Bond Activation

General Characteristics Carbon-carbon bonds are among the strongest in organic compounds. Activating them for useful chemical transformation is one of the newest and biggest challenges in organic ...

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Crabtree’s Catalyst

Crabtree’s Catalyst

General Characteristics [Ir(cod)(PCy3)(Py)]PF6 is an easily handleable cationic iridium complex used as a homogeneous hydrogenation catalyst. The complex was developed by Robert Crabtree of Yale ...

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Giese Radical Addition

Giese Radical Addition

General Characteristics Carbon free-radicals (generated from organic halides, the Barton esters, etc.) are nucleophilic and can be trapped with various electrophiles. In particular, trapping of ...

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Hayashi-Jørgensen Catalyst

Hayashi-Jørgensen Catalyst

General Characteristics The diarylprolinol silyl ether organocatalysts facilitate various asymmetric reactions of aldehydes by forming active enamine and/or iminium intermediates. These catalysts are ...

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O-Acylisopeptide Method

O-Acylisopeptide Method

General Characteristics The peptides in which the serine and/or threonine residues are isomerized from amide to ester (with their side chain hydroxyl group) are called O-acylisopeptides. ...

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Rothemund-Lindsey Porphyrin Synthesis

Rothemund-Lindsey Porphyrin Synthesis

General Characteristics Meso-substituted porphyrins are synthesized by condensation of aldehydes and pyrroles followed by oxidation. The early methods needed forcing conditions but the improvements ...

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Julia-Kocienski Olefination

Julia-Kocienski Olefination

General Characteristics The original Julia olefination procedure was somewhat inconvenient as it required three operations (nucleophilic addition, acetylation, and elimination using toxic Na ...

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Organotrifluoroborate Salts

Organotrifluoroborate Salts

General Characteristics Organotrifluoroborate salts (R-BF3–) are stable towards heat, air, and moisture, and are convenient crystalline reagents. Because of the tetra-coordinated borate ...

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