Monthly Archives: May 2017

de Mayo Reaction

de Mayo Reaction

General Characteristics In the de Mayo reaction, 1,3-dicarboyl compounds and alkenes undergo photo-activated [2+2] cycloaddition. The subsequent ring opening gives 1,5-dicarbonyl products. General ...

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Cornforth Rearrangement

Cornforth Rearrangement

General Characteristics Oxazole compounds containing a carbonyl group at 4-position are known to undergo thermally driven rearrangement. Thiazoles have the similar property as well. General ...

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Reductvie Desulfurization

Reductvie Desulfurization

General Characteristics Thioethers and thioacetals can be reductively desulfurized by treating them with Raney nickel. The reduction of the latter is a common way to deoxygenate carbonyl groups. ...

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Blaise Reaction

Blaise Reaction

General Characteristics In the Blaise reaction, nitriles and zinc-enolates (prepared from zinc and α-haloesters) react to give β-enaminoesters or β-ketoesters. General References Blaise, E. E. Compt. ...

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Synthesis of N-Oxide

Synthesis of N-Oxide

General Characteristics Amines are susceptible to oxidation. Tertiary amines are oxidized to give N-oxides. Secondary amines having proton(s) at the α-position are oxidized to nitrones. The ...

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Red-Al

Red-Al

General Characteristics Sodium bis(2-methoxyethoxy)aluminum hydride is a reducing agent sold with the common name Red-Al or Vitride. Red-Al can selectively reduce nitriles to aldehydes. It is more ...

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L/N/K-Selectride

L/N/K-Selectride

General Characteristic The reagents having the formula M[HB(sec-Bu)3] are used as reducing agents. There are three types with different cations: L-Selectride (lithium), N-Selectride (sodium), and ...

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Conia-Ene Reaction

Conia-Ene Reaction

General Characteristics In the Conia-ene reaction, the enol and the alkene or alkyne parts of an unsaturated carbonyl compound react and undergo intramolecular cyclization. General References ...

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Manuel Alcarazo

Manuel Alcarazo

Manuel Alcarazo (born in 1978, Spain) is a Professor at the University of Göttingen. (The photo is quoted from the laboratory HP) Education and Experiences 2005 PhD, the Instituto de Investigaciones ...

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Bucherer-Bergs Hydantoin Synthesis

Bucherer-Bergs Hydantoin Synthesis

General Characteristics Hydantoins can be synthesized from the corresponding ketones or aldehydes using potassium cyanide and ammonium carbonate. General References Bergs H, DE, 566, 094, 1929 ...

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