Monthly Archives: January 2015

Benzoin Condensation

Benzoin Condensation

General Characteristics In the presence of nucleophilic catalysts such as cyanide, aromatic aldehydes dimerize to form products called benzoins. Benzoin derivatives are important intermediates for ...

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Masamune-Bergman Reaction

Masamune-Bergman Reaction

General Characteristics When heated at above 200 °C, cis-1,5-hexadiyne-3-ene cyclizes to form 1,4-benzene biradical. The highly reactive biradical species becomes benzene in the presence of hydrogen ...

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Directed Ortho Metalation

Directed Ortho Metalation

General Characteristics Ortho-selective functionalization of aromatic compounds is possible for the substrates having appropriate directing atoms or groups. Directed ortho metalation (abbreviated as ...

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Knochel-Hauser Base

Knochel-Hauser Base

General Characteristics TMPMgCl-LiCl is known as the Knochel-Hauser base and a useful reagent for directed metalation of aromatic compounds. The metalation of aromatic compounds are conventionally ...

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Turbo Grignard Reagent

Turbo Grignard Reagent

General Characteristics The addition of one equivalent of lithium chloride when preparing Grignard reagents accelerates both the metal-halogen exchange and the insertion of magnesium. RMgCl-LiCl is ...

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Borane Complexes (BH3・L)

Borane Complexes (BH3・L)

General Characteristics Uncomplexed borane (BH3), which usually exists as diborane (B2H6), is difficult to handle since it is a toxic and pyrophoric gas. When complexed with THF or dimethylsulfide, ...

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