Mukaiyama Condensation Reagent

Mukaiyama Condensation Reagent

Overall Score4
  • Generality
  • Reagent Availability
  • Experimental User Friendliness
  • General Characteristics

First introduced in 1970’s, 2-halo-N-alkylpyridinium salts are called the Mukaiyama reagent and used for condensation reactions such as esterification and amide bond formation.

  • General References

・Narasaka, K.; Maruyama, K.; Mukaiyama, T. Chem. Lett. 1978, 885. doi:10.1246/cl.1978.885
・Review for macrolactonization: Parenty, A.; Moreau, X.; Campagne, J.-M. Chem. Rev. 2006, 106, 911. DOI: 10.1021/cr0301402

  • Reaction Mechanism

  • Examples

The synthesis of prostaglandin F-lactone.[1]

An application to macrolactamization.[2]

  • Experimental Procedure

  • Experimental Tips

  • References

[1] Narasaka, K.; Maruyama, K.; Mukaiyama, T. Chem. Lett. 1978, 885. doi:10.1246/cl.1978.885

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