イー・タン（Yi Tang、19xx年xx月xx日-）アメリカの天然物化学者。カリフォルニア大学ロサンゼルス校（UCLA）教授。
経歴
PROFESSIONAL EXPERIENCE
2010- University of California, Los Angeles Professor, Department of Chemical and Biomolecular Engineering
2010- Professor, Department of Chemistry and Biochemistry
2009- Samueli Fellow, UCLA School of Engineering and Applied Science
2009- Member, California NanoSystems Institute (CNSI)
2008- Member, Jonsson Comprehensive Cancer Center, Cancer Cell Biology Program 2008-2010 Associate Professor, Department of Chemical and Biomolecular Engineering
2004-2008 Assistant Professor, Department of Chemical and Biomolecular Engineering
EDUCATION
2002-2004 NIH Postdoctoral Fellow, Stanford University
1997-2002 Ph.D., Chemical Engineering, California Institute of Technology
1994-1997 B.Sc., Chemical Engineering, Material Science and Engineering, Pennsylvania State University
受賞歴
2012 American Chemical Society (ACS) Arthur C. Cope Scholar Award
2011 The Saville Lecturer at Department of Chemical and Biological Engineering, Princeton University
2011 American Chemical Society Division of Biochemical Technology (BIOT) Young Investigator Award
2010 National Academy of Engineering (NAE) Frontiers in Engineering Invitee
2010 Society for Industrial Microbiology (SIM) Young Investigator Award (2010)
2009 American Institute of Chemical Engineers (AIChE) Allan P. Colburn Award
2009 Sloan Research Fellowship
2008 Department of Defense Breast Cancer Research Program (BCRP) Concept Award
2008 The Camille Dreyfus Teacher Scholar Award
2007 The David and Lucile Packard Foundation Fellowship
2007 UCLA Faculty Career Development Award
2006 Presidential Early Career Award in Science and Engineering (PECASE)
2006 National Science Foundation CAREER Award
2005, 2006 UCLA AIChE Student Chapter Professor of the Year Award
2005 American Heart Association National Scientist Development Grant Award
2002 National Research Service Award, National Institute of Health
1997 Whitaker Graduate Research Fellowship in Biomedical Engineering
2000 Caltech 10K Business Plan Competition Winner
1999 Constantin Economou Award for Excellency in Graduate Research
1993 Elizabeth and Holmes Memorial Scholarship
1995 Dow Chemical Co. Outstanding Student in Material Science and Engineering
1995 The 1934 Penn State Alumni Scholarship Award
研究概要
1.天然物の生合成
streptomyces属由来の芳香族ポリケタイドの生合成やNRPSの生合成研究を行なっている。また、生合成研究により得られた知見を元に、非天然物をコンビナトリアル生合成によって生産することも研究している。[1]
2.生体触媒、酵素エンジニアリング
医薬品の合成、半合成に用いることのできるような生体触媒の研究を行っている。[2]
3.生体材料
癌治療、イメージング、リプログラミングなどの応用を視野に入れた、様々な生体分子の細胞、モデル動物への輸送法の開発を行っている。
関連文献
[1] (a) Cacho, R. A. Chooi, Y., Zhou, H., Tang, Y.* “Complexity Generation in Fungal Polyketide Biosynthesis: aSpirocycle-Forming P450 in the Concise Pathway to the Antifungal Drug?Griseofulvin.” ACS Chem. Biol. 2013, in press. (b) Ma, S. A., Li, J., Choi, J. W., Zhou, H., Lee, M., Moorthie, V., Xie, X., Kealey, J. T., Da Silva, N. A., Vederas, J. C.*,Tang, Y.* “Complete Reconstitution of a Highly-Reducing Iterative Polyketide Synthase.” Science 2009, 326, 589-592. DOI: 10.1126/science.1175602 [2] Xie, X., Wong, W. W.,Tang, Y.*”Improving Simvastatin Bioconversion in?Escherichia coli?by Deletion of?bioH.” Metab. Eng.2007, 9, 379-386. DOI :10.1016/j.chembiol.2009.09.017
