ベン・シェン（Ben Shen, 19xx年xx月xx日-）はアメリカの天然物化学者。スクリプス研究所教授。
経歴
1982, B.S., Chemistry, Hangzhou University, China
1984, M.S., Chemistry, The Chinese Academy of Sciences, China
1991, Ph.D., Organic Chemistry and Biochemistry, Oregon State University, Corvallis, OR
1991-95, Postdoctoral Research Associate, School of Pharmacy, UW-Madison, WI
1995-01, Assistant Professor, Department of Chemistry, University of California, Davis, CA
2001-03, Associate Professor, School of Pharmacy and Department of Chemistry, UW-Madison, WI
2004-10, Professor, School of Pharmacy and Department of Chemistry, UW-Madison, WI
2004-10, Charles M. Johnson Distinguished Chair, School of Pharmacy, UW-Madison, WI
2005-10, Principal Investigator, NCI UW National Cooperative Drug Discovery Group, Madison, WI
2011-, Professor, Departments of Chemistry and Molecular Therapeutics, TSRI, Jupiter, FL?
2011-, Director, The Natural Products Library Initiative at TSRI, TSRI, Jupiter, FL
受賞歴
1996-01, FIRST Award, NIH
1997-00, Searle Scholar, Searle Scholars Program?1998-03, CAREER Award, NSF
2000, Matt Suffness Award, American Society of Pharmacognosy
2001-06, Independent Scientist Award, NIH
2002, Jack L. Beal Award, American Society of Pharmacognosy
2011, Fellow, American Academy of Microbiology
2011, Fellow, American Association for the Advancement of Science
2002-, Member, Editorial Board of J. Ind. Microbiol. Biotechnol.
2002-, Member, Editorial Advisory Board of J. Nat. Prod.
2005-, Member, Editorial Board of Current Bioactive Compounds
2005-, Member, Advisory Board of Molecular BioSystems
2006-, Member, Editorial Board of Recent Patents on Anticancer Drug Discovery
2007-, Associate Editor, Acta Microbiologica Sinica
2009-, Member, Editorial Board of Journal of Antibiotics
2011, Guest Co-Editor, J. Antibiot. January issue in memory of C. Richard Hutchinson
2012, Guest Co-Editor, Curr. Opinion Chem. Biol. April issue on Biocatalysis and Biotransformation
2017-, Editor, J. Ind. Microbiol. Biotechnol.
研究概要
抗腫瘍性抗生物質 C-1027 は、腫瘍細胞の2本鎖DNA切断に由来する非常に強力な抗腫瘍性 を発揮するクロモフォアと、それを包接して安定化するアポタンパク質との 1:1 複合体である。C-1027はFig.1に示すように極めて不安定な9員環共役エンジイン構造を核とする複雑な構造を有することから、全合成研究でも注目を集めてきた。
Ben Shenらのグループは、C-1027の遺伝子クラスターを同定し、その生合成を明らかにした。
図は全て論文中より引用
関連文献
- ’’Biosynthesis of the Enediyne Antitumor Antibiotic C-1027’’ Wen Liu, et al. Science 297, 1170 (2002) DOI: 10.1126/science.1072110
- Stern-Ginossar, N.; Weisburd, B.; Michalski, A.; Le, V. T. K.; Hein, M. Y.; Huang, S.-X.; Ma, M.; Shen, B.; Qian, S.-B.; Hengel, H.; Mann, M.; Ingolia, N. T.; Weissman, J. S. Science 2012, 338, 1088.
