“An efficient InCl3-catalyzed hydration of nitriles to amides: acetaldoxime as an effective water surrogate”
E. S. Kim, H. S. Lee, S. H. Kim, J. N. Kim, Tetrahedron Lett. 2010, 51, 1589. DOI: 10.1016/j.tetlet.2010.01.063
An efficient InCl3-catalyzed hydration protocol of nitriles to amides was developed. The reaction was carried out in toluene at refluxing temperature with the aid of acetaldoxime as an effective water surrogate to produce amides in high yields.