概要
エナミンとエチニルケトンを縮合させることでできるアミノジエン中間体から環化を起こすことでピリジン環が合成できる。
基本文献
- Bohlman, F.; Rahtz, D. Chem. Ber. 1957, 90, 2265. DOI: 10.1002/cber.19570901021
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- Bagley, M. C.; Glover, C. Synlett 2007, 2459. DOI: 10.1055/s-2007-986674
反応機構
反応例
Promothiocin Aの全合成[1]
参考文献
- Bagley, M. C.; Bashford, K. E.; Hesketh, C. L.; Moody, C. J. J. Am. Chem. Soc. 2000, 122, 3301. DOI: 10.1021/ja994247b
関連書籍
[amazonjs asin=”3527327479″ locale=”JP” title=”The Chemistry of Heterocycles: Structures, Reactions, Synthesis, and Applications 3rd, Completely Revised and Enlarged Edition”][amazonjs asin=”0471302155″ locale=”JP” title=”Name Reactions in Heterocyclic Chemistry (Comprehensive Name Reactions)”][amazonjs asin=”0470085088″ locale=”JP” title=”Name Reactions in Heterocyclic Chemistry II (Comprehensive Name Reactions)”]関連リンク
- Bohlmann-Rahtz Pyridine Synthesis (organic-chemistry.org)
- Bohlmann-Rahtz Pyridine Synthesis (SynArchive)
